Exosomal miRNAs in tumor microenvironment

Exosomal miRNAs in tumor microenvironment

Blog Article

Abstract Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting Differential of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as exosomes and cytokines.Exosomes are tiny extracellular vesicles (40-160nm) containing active substances, such as proteins, lipids and nucleic acids.Exosomes carry biologically active miRNAs to shuttle between tumor cells and TME, thereby affecting tumor development.Tumor-derived exosomal miRNAs induce matrix Solenoid Assembly reprogramming in TME, creating a microenvironment that is conducive to tumor growth, metastasis, immune escape and chemotherapy resistance.

In this review, we updated the role of exosomal miRNAs in the process of TME reshaping.